WHAT IS UNCONTROLLED gMG?

Watch the video to see how uncontrolled gMG affects patients living with the condition

 

 

For a large portion of patients, muscle weakness can be uncontrolled and the risk of serious events can be unpredictable.1,4,7,9

Working with your patients to recognize the true impact of gMG on their daily lives will help uncover those with uncontrolled disease.

THE HALLMARKS OF UNCONTROLLED gMG

~50% of patients (N=1140)

had moderate-to-severe gMG, defined as having a Myasthenia Gravis Activities of Daily Living (MG-ADL) score of 6 or above1*

26% of patients (N=372)

required IVIg within a 6-month period due to exacerbations or inability to reduce maintenance therapy8

~20% of patients (N=188)

will experience a potentially life-threatening myasthenic crisis requiring intubation at least once during their lifetime7,13

36% of patients (N=372)

report their treatments impact their ability to lead a normal life8

50-77% of patients (n=398)

50% of men and 77% of women reported intolerable side effects while taking prednisone10

UP TO
50% of patients (N=1077)

reported current disease symptoms associated with an unsatisfactory symptom state3,6,12

 

LEARN MORE ABOUT IDENTIFYING UNCONTROLLED gMG

 

THE gMG DISEASE EXPERIENCE CAN
FEEL UNPREDICTABLE

For patients with chronically uncontrolled gMG, instability and 
unpredictability are ever present.4,9

stable remission

79-90% of patients never reach complete stable remission13,14‡
(n=677)

fluctuations

Fluctuations can be spontaneous, varying from day to day and from hour to hour9

INITIAL

INITIAL

~2-3 years

After being diagnosed, symptoms typically worsen,
reaching their peak within the first 2 years. But for 1 in 5 people, worsening symptoms may continue after 2 years.4

CONTINUAL

CONTINUAL

After the initial stage, people may continue to experience unpredictable and serious symptoms.1,7,15

 

 

EXACERBATIONS ARE UNPREDICTABLE

Although some triggers of intermittent worsening of symptoms have been identified, they 
are not well understood, making the disease experience feel unpredictable for patients.4,9

IDENTIFIED TRIGGERS INCLUDE4,16:

  • Mental and physical stress
  • Seasonal changes
  • Infections
  • Certain medications
  • Vaccinations

21-43%of patients

experienced ER visits and hospitalizations over the course of 6 months7‡ (n=76-741)

69% of patients

who experienced a myasthenic crisis have no identified precipitating factor11
(n=188)

*In a cross-sectional analysis of patients with gMG who had a mean duration of disease of 9.9 years.

**Patient Acceptable Symptom State (PASS) is a 1-question-based score that has been validated in multiple chronic inflammatory diseases including MG.

† The MGFA Post-intervention Status (MGFA-PIS) defines complete stable remission as having no symptoms or signs of gMG for at least 1 year and receiving no therapy during that time

‡In a retrospective analysis of patients with a diagnosis of gMG for ≥2 years who enrolled in the Myasthenia Gravis Foundation of America (MGFA) Patient Registry.

SEE HOW gMG IMPACTS A PATIENT’S DAILY LIFE

 

WATCH GREG'S STORY

Explore the Cause of gMG    >

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