For a large portion of patients, muscle weakness can be uncontrolled
and the risk of serious events can be unpredictable.1-3,7

~75% of patients (n=609)

followed over 4 decades reported moderate-to-severe weakness2

21-43% of patients (n=728-741)

experienced ER visits or hospitalizations over the course of 6 months3*

50% of patients (N=1140)

had moderate-to-severe gMG, defined as having a Myasthenia Gravis Activities of Daily Living (MG-ADL) score of 6 or above1†

48% of patients (n=190)

with MG-ADL scores of 6 and above feel like their ability to perform daily routines is considerably impaired8

THE gMG DISEASE EXPERIENCE CAN
FEEL UNPREDICTABLE

The gMG disease experience can feel unpredictable

For patients with chronically uncontrolled gMG, instability and
unpredictability are ever present.2,7

Image
stable remission

79-90% of patients never reach complete stable remission9,10‡

Image
fluctuations

Fluctuations can be spontaneous, varying from day to day and from hour to hour7


 

INITIAL

Increasing weakness reaching maximal severity2

~2-3 Years

CONTINUAL

Ongoing unpredictable and debilitating symptoms, and risk of exacerbations and crises1,3,11

  • INITIAL

    Increasing weakness reaching maximal severity2

    ~2-3 Years

  • CONTINUAL

    Ongoing unpredictable and debilitating symptoms, and risk of exacerbations and crises1,3,11


EXACERBATIONS ARE UNPREDICTABLE

Although some triggers of intermittent worsening of symptoms have been identified, they
are not well understood, making the disease experience feel unpredictable for patients.2,7

IDENTIFIED TRIGGERS INCLUDE2,12:

  • Mental and physical stress
  • Seasonal changes
  • Infections
  • Certain medications
  • Vaccinations

20% of patients

will experience a potentially life- threatening myasthenic crisis requiring intubation at least once during their lifetime3,13

69% of patients

who experienced a myasthenic crisis have no identified precipitating factor13